Pulya A. Synthesis, structure, properties of 3d-metals coordination compounds with benzоdiazepine and pyridine ligands of hydrazide-hydrazone type

The work is devoted to the actual problem of obtaining the new coordination compounds of 3d metals with benzodiazepine and pyridine ligands of hydrazide hydrazone type, which are promising as effectors of enzymes, new generation drugs with a wide spectrum of pharmacological action. The techniques were, which use spontaneous self-assembly, for which 39 compounds were synthesized, including new 24 benzodiazepines and 12 pyridine-containing metal chelates, were developed. Their spectral, magnetic properties were investigated. For the first time hydrazone was synthesized by the interaction of hydazepam with salicylic aldehyde. Its individuality, purity, molecular and crystalline structure were proved by the methods: thermogravimetry, IR, UV, NMR spectroscopy, mass spectrometry, X-ray diffraction. New complexes of Co(II), Ni(II), Cu(II), Mn(II), Zn(II) with hydazepam and its condensation products with salicylic aldehyde, isatin, pyruvic acid were synthesized. The principal possibility of using synthesized metal chelates as effectors of enzymes, antimicrobial and analgesic agents is shown.