Cherniakova H. Experimental substantiation of applying antibacterial preparations in combination with nanocomposites for treatment of burn infections

Object – causative agents of burn infection, samples of new applicative bionanocomposite for local treatment of thermal burns; aim – to improve the efficiency of treatment of infected burn wounds by applying new complex antimicrobial preparations made using nanocomposite materials and antibiotics of various chemical groups; methods – microbiological, biological, biochemical, immunological, planimetric, histological, mathematical and statistical ones; results – supplemented data on the etiological factors of infectious complications in patients with burns of varying degrees of severity; it was determined that the leading causes of wound infections are S. aureus and P. aeruginosa; a detailed study of the antibiotic sensitivity of these pathogens in a modern burn hospital was conducted and a high level of resistance of clinical isolates of S. aureus to ceftriaxone and carbapenems was revealed; for the first time, the antibacterial properties of experimental samples of applicative bionanocomposites of application were studied for clinical strains of S. aureus and P. aeruginosa in vitro; it was established that local application of the sorbent with 0.1% levofloxacin reduces the microbial contamination of the wound below the critical level on the 3rd day of observation; for the first time, a detailed study of the effect of bionanocomposite with 0.1% levofloxacin and 15.0% sulfamethoxazole on microbiological, biochemical, immunological and histological indicators of experimental animals disturbed due to thermal burn and infection with Pseudomonas bacillus was conducted, and it was found that the use of an application sorbent with 0.1 % levofloxacin contributes to their faster normalization; based on the results of the improvement of the above indicators in animals with a model Pseudo-Pelvic burn infection, the expediency of using a bionanocomposite with 0.1% levofloxacin for the prevention and treatment of burn wound infections caused by opportunistic bacteria; branch – medicine.