Shcherbak O. Treatment optimization of patients with ischemic heart disease in combination with nonalcoholic steatohepatitis, taking into account liver functional state.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0418U003983

Thesis Registration Form

0418U003983.pdf

Applicant for

Specialization

  • 14.01.02 - Внутрішні хвороби

23-11-2018

Specialized Academic Board

Д 20.601.01

SHEI “Ivano-Frankivsk national medical university”

Essay

The dissertation is devoted to the increase of the efficiency of pathogenetic treatment of patients with ischemic heart disease (IHD) in combination with nonalcoholic steatohepatitis (NASH). 122 patients with stable IHD functional class II were examined, of which 59 (48.4%) patients had concomitant NASH. It has been shown that with the increased transaminases activity the prooxidant-antioxidant dysbalance and endothelial dysfunction are observed. The relationship between serum triglyceride level increase and L-carnitine content was found. The prescription of ursodeoxycholic acid in combination with L-carnitine potentiates the hypolipidemic effect of median therapeutic doses of rosuvastatin and can influence the leading pathogenetic mechanisms of IHD progression. Key words: ischemic heart disease, nonalcoholic steatohepatitis, atherogenic dyslipidemia, rosuvastatin, L-carnitine, ursodeoxycholic acid. Branch - Medicine.

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