The dissertation is dedicated to analyse the occurrence frequency of the lateral ventricle meningiomas in the structures of primary lateral ventricular tumors, which were operated in a number of institutions of Ukraine, determining their clinical features, outcome, and complications related to surgery. As well as improving the diagnosis and optimizing the results of surgical treatment, taking into account access and techniques for their removal. The work is based on the analysis of a retrospective and prospective multicentric study. To realize this goal and to solve specifically defined tasks, carefully analyzed 275 history of disease patients with primary lateral ventricular tumors were thoroughly analyzed, among which 52 cases of LVM. Subjects were treated in 6 neurosurgical institutions in Ukraine at SI "Institute of Neurosurgery named after Acad. A.P. Romodanov NAMS Ukraine"( n=25, including 1 patient who was further operated in Кyiv Regional Clinical Emergency Hospital KREH), KREH (n=13), Clinical Hospital Feofaniya (n=5), as well as Regional Clinical Hospital Dnipro (n=6), Uzhhorod (n=3), Rovne (n=1) between 1990 and 2016. The study analyzed the clinical features, outcome, and complications related to surgery was done. As well as improving the diagnosis and optimizing the results of surgical treatment, were identified. The average age of the subjects was 44,37 ± 16,24 years (15,9 to 74,8 years). The period from the onset of clinical symptoms to the diagnosis ranged from 3 weeks to 20 years (median 1 year, interquarterly interval of 0,44 to 2 years). Meningiomas of the lateral ventricles are usually manifested by symptoms associated with increased intracranial pressure, and can reach significant size before the diagnosis is established. The average duration of symptoms before diagnosis is 2 years. Clinical manifestations of the tumor upon admission to the hospital were characterized by severe cerebral symptoms and, less frequently, focal symptoms. The most common headaches were hypertensive (100%), followed by visual field deficits (71,1%), static coordination impairments (walking unsteadiness (61,5%), dizziness (19,2%), ataxia (1,9%)), contralateral pyramidal movement disorders, including a positive Barr? test (36,5%), central facial paresis (11,5%), speech (aphasic) disorders (21,15%), impaired consciousness (21,1%), impairment of consciousness (21,1%), memory impairment (21,2%), muscle tone change - 19,2% (increased in 11,5% and decreased in 7,7%), hemotype sensitivity disorders (17,3%) mental disorders (15,4%), astenoneurotic syndrome (15,4%), vomiting (13,5%), epileptiform fits (11,5%), tremor (11,5%), Muscle tone was elevated in 11,5% and decreased in 7,7%.), nausea (9,6%), disturbance of pelvic organs function (1,9%). According to CT data, the density of meningioma is presented by hypodensitive mass - 30 cases (73,8%), isodensic - 11 cases (26,8%). MRI was performed in 35 patients (67,3%), 21 of whom were contrasted, and 14 were performed without contrast. The main method of surgical treatment was the removal of the meningioma of the lateral ventricle (open access surgical approach - total 49): operated once (n=43), reoperated (n=5), operated more than twice (n=1), not operated (n=3, including one patient who received radio surgery). Tumor resection was performed: totally (n=36), subtotal (n=12), partially (n=1); 3 cases additionally underwent and held ventriculoperitoneal-shunt). Radiosurgery was performed on one patient, conservative treatment for two. Patients who received radiation were prescribed with recommended doses and the causes of submission were studied (adjuvant therapy or recurrence). The results of surgical interventions were evaluated after the onset of clinical and laboratory remission and according to the MRI of the brain, which was performed 6 months after the operation. The dependence of the results of treatment (relapse occurrence) depended on radicality of the tumor removal taking into account the localization and histological structure was analyzed. The factors influencing the result of surgical intervention and the quality of life of the patient are determined. An algorithm has been developed for managing patients and selecting access for various localizations of tumor mass located in the lateral ventricle. The immediate and long-term results and complications in patients after various types of surgical intervention have been analyzed.Postoperative neurological deficit was observed in 13 patients, one of witch was dealing with transient deficit regressing before his discharge in-patient unit, 12 patients had persistent changes of various severity leding to disability. Intra- and extracranial complications of surgical treatment occurred in 9 patients; two of them had mixed. Complication in 3 cases in the early postoperative period, such complications proved lethal in the early post-operative period. Another patient died 6 months later due to hemorrhage to the brainstem on the background of continued growth of the tumor.
