Object: ankle joint, malleolus fracture, injuries of tibiofibular syndesmosis. Aim: to improve the results of treatment of patients with malleolus fractures and injuries of tibiofibular syndesmosis by experimental and clinical justification of the methods of surgical treatment with dynamic fixation of tibiofibular syndesmoses. Methods: clinical, radiological, magnetic resonance, basometric, statistical, biomechanical, experimental, comparative analysis of clinical material. For the first time in the experiment, a comparison of the mobility parameters in the ankle joint was carried out under conditions of its dynamic fixation using one and two tension band wiring. On the basis of mathematical modeling, new knowledge was obtained regarding the determination of the optimal position of the tension band wiring in fixing the tibiofibular syndesmosis. For the first time as a result of the mathematical modeling of the stress-deformed state of the system "fixator-bone", the strength and stiffness of the osteosynthesis of the lateral malleoulus fractures with the proposed plates were proved. By means of baseometric hardware and software study indices of patients with dynamic fixation of tubiofibular syndesmosis in case of malleolus fractures, new knowledge was obtained regarding the restoration of the resistance coefficient and the rotation of center pressure in case of the proposed method of surgical treatment using. Fixators for the treatment of patients with ankles fractures with damage of tibiofibular syndesmosis have been developed, which provide high strength and stiffness of the lateral malleolus osteosynthesis with the preservation of physiological mobility at the level of tibiofibular syndesmosis (Patents of Ukraine №95304 and №103315). The method of surgical treatment of patients with ankle fractures with damage of tibiofibular syndesmosis with the help of one or two tension band wiring, taking into account the type of damage and the degree of its instability, the use of which significantly reduces the risk of complications in the postoperative period, eliminates the need for stage surgical interventions, allows to perform the early rehabilitation. The possibility of early and active medical rehabilitation has been substantiated, which made it possible to achieve high treatment efficiency - the average value on the AOFAS scale after 12 months after the operation was 92.5 points, excellent and good results were obtained in 95.46 %. The results of the dissertation research were introduced into the clinical practice of the SI "Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine", SI "Institute of Traumatology and Orthopedics National Academy of Medical Sciences of Ukraine", KZOZ "Regional Clinical Hospital - Emergency Care Center and Disaster Medicine", KU " Zaporizhzhia Regional Clinical Hospital", KU "Odessa Regional Clinical Hospital", Department of Traumatology, Motor Sich JSC Therapeutic-and-health-improving Centre, Zaporizhzhia. Traumatology and Orthopaedics.