Mankovskyi G. Long-term outcomes of revascularization of myocardim in patients with coronary artery disease and violation of carbohydrate metabolism.

The dissertation is aimed to investigate the damage of coronary arteries depending on impairments of carbohydrate metabolism and to reveal the prevalence of overt diabetes mellitus, prediabetes and insulinresistance in patients with ischemic heart disease before and after revascularization of myocardium. The analysis of the relationship between angiographically assessed structure of coronary arteries and impairments of carbohydrate metabolism in patients with ischemic heart disease allowed to find out that the presence of type 2 diabetes mellitus or prediabetes moderately correlates with the number of coronary arteries affected by atherosclerotic lesions and correlates strongly with extent of those lesions in coronary arteries. This study is the first one which has shown the positive correlation between the presence and extent of atherosclerotic damage of coronary arteries and degree of the impairments of carbohydrate metabolism.The frequently non-recognized risk factor such as impairment of carbohydrate metabolism was emphasized in patients with multiple vessels damage of coronary arteries. It was shown for the first time that the highest degree of hyperinsulinemia which reflects the existing insulin resistance correlates with the greater extent of angiographically confirmed atherosclerotic damage of all three coronary arteries in patients with ischemic heart disease without diabetes mellitus.