Tumanov V. Pathomorhology and pathogenesis for spontaneous poisoning birds with diazinon

The dissertation is devoted to study of pathogenesis and questions of pathomorphological diagnostics of spontaneous poisoning of birds with phosphororganic pesticide diazinon. This drug is often used for unauthorized poisoning of wild and domestic birds. It was established that the basis of the pathogenesis of diazinone poisoning is the marked decrease in the activity of acetylcholinesterase, which leads to a violation of nerve impulses, the appearance of tremor and paresis of wings, opistotonus, and in the future of paralysis. In the terminal periods of the disease, the development of cardiovascular and pulmonary insufficiency was noted. In the pathoanatomical study, the pronounced complex of pathoanatomical changes was recorded: significant and persistent corneal eruption, cyanosis of the skin and subcutaneous tissue, dyscirculatory changes (acute congestive hyperemia, stasis, perivascular edema and hemorrhages) in the internal organs accompanied by dystrophic and necrotic changes of hepatocytes, nephrocytes, cardiomyocytes, brain neurons), with no perifocal inflammatory changes. The lungs recorded a pronounced expansion and overflow of arterial and venous vessels of different caliber, as well as an increase in the number of mucus in the bronchi. 23 % of experimental animals developed catarrhal bronchopneumonia, sometimes with hemorrhagic accent, and in 6 % of cases, hemorrhagic pneumonia. For the study of the brain were hyperemia, stasis, diapedeous hemorrhage, perivascular edema, severe changes in nerve cells. An electron microscopic study also found destruction of synapses in the cerebral cortex, cerebellum and medulla oblongata, indicating a violation of nerve impulses.