Andriushkova N. Role of enteroviral infection in development of acute cerebrovascular disease.

The dissertation is focused on research of the role of enteroviral infection in the development of acute cerebrovascular disease (ACVD). By experimental research results it was established for the first time that the enteroviral genome was isolated reliably higher in the blood sera of patients with the ACVD of the main group than that of patients of the comparative group (23.6±5.9% and 2.9±2.8% respectively, p<0,05). The strains of enteroviruses: the Coxsackie-B viruses (serotypes 2, 3, 4) and the ECHO-viruses (serotypes 6, 9, 27 (two serotypes), 29) as well as three unidentified serotypes were isolated and identified in the blood of patients with the ACVD. It was established that enteroviruses' isolates under research have certain genetic features and they can be considered as auxiliary in research of the enteroviruses role in the ACVD development. The presence of Ig M and Ig G, which were specific to enteroviruses, was established in the blood sera of patients of the main group. The assumption was made on the persistent character of the enteroviral infection of patients with the ACVD. The possible trigger role of the acute and persistent enteroviral infection in the ACVD development was determined. The dissertation results show that the necessity of combination of the classic virology, molecular-genetic and serologic methods for isolation of enteroviral infection in patients with the ACVD was scientifically grounded.