Gumenyuk A. Morphological changes of the hippocampus in reactivation of the herpes simplex virus type 1 in the presence of experimental hemorrhagic stroke and pharmacocorrection

The dissertation is devoted to the study of morphological changes of the hippocampus in reactivation of the herpes simplex virus type 1 in the presence of experimental hemorrhagic stroke and antiviral pharmacological correction. There was stated the acute interruption of the blood supply is the factor of reactivation of latent herpesvirus infection and progression of the neurodystrophy. The administration of antiviral drugs after intracranial hemorrhage modelling in infected animals suppresses reactivation of HSV-1, according to the cytopathic action titre in Vero cell culture, and hippocampal neurodystrophy, confirmed by light microscopy and morphometric analysis. On the basis of results of immunohistochemical research and morphometric evaluation the development of astrogliosis was revealed which significantly increased in the presence of combined pathology. The suppression of astrogliosis at administration of acyclovir, altabor and neoflazid has been shown. That concluded on possibility of GFAP level usage as indication of the degree of brain damage under neuroinfection and for evaluation of the effectiveness of antiviral pharmacological correction. According to the results of electron microscopy study unspecific ultrastructural changes of pyramidal neurons, its processes, vascular endothelium in herpetic infection, hemorrhagic stroke and combined pathology has been shown. It was stated the suppression of development of dystrophic changes of endothelium in pharmacological correction of herpetic infection by acyclovir and altabor.