Dzyhar O. Secondary tumor lesion of the liver: diagnosis and evaluation of the effectiveness of radiosurgical treatment with magnetic resonance and multi-detector computed tomography.

The dissertation presents the results of clinical research, during which a number of scientific tasks were solved, which allowed to achieve the set goal - to improve the efficiency of evaluation of the results of radiosurgical treatment of patients with secondary tumor lesion of the liver, the development of CT and MRI predictors and prediction of survival. The basis of the dissertation work is the analysis of the results of radiation diagnosis and radiosurgical treatment of 70 patients with secondary tumor lesions of the liver, who were examined and treated in the period from 2010 to 2018 in the diagnostic department of LLC "Medical Center named after Acad. Yu.P. Spizhenko "of TM" Spizhenko Clinic ", which is the clinical base of the Department of Radiology of the National Medical Academy of Postgraduate Education named after P. L. Shupyk. The work presents the evaluation of secondary tumor lesions of the liver before and after exposure to stereotactic radiosurgery. Quantitative indicators of the local response of the centers of the liver after radiosurgical treatment, the status of the centers by the system RECIST 1.1 were determined. MRI and MDCT predictors of progression or regression of metastatic lesions after radiosurgical exposure have been determined and statistically proven. The most statistically significant predictor is the quantitative MRI scan scan. Determined MRI and MDCT predictors affecting overall survival of patients with secondary tumor lesions undergoing stereotactic treatment. The most statistically significant predictor was established - the quantitative diffusion index and the proposed INDEX indicator, which characterizes the reaction of the metastatic hearth of the liver after radiosurgical treatment at the first radiation control study. The prognostic model of survival is developed that allows to predict the terms of survival, and in case of a negative prognosis, changes in treatment tactics.