Ruzhanska V. The role of AT1-receptor gene polymorphism in diagnostic and predictive informativeness of galectin-3 and brain natriuretic peptide in hypertension in males.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0419U001693

Thesis Registration Form

0419U001693.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

19-11-2019

Specialized Academic Board

Д 26.616.01

State Institution "National Scientific Center "Institute of Cardiology named after academician M.D. Strazhesko" of the National Academy of Medical Sciences of Ukraine

Essay

Dissertation is devoted to the optimization of antihypertensive therapy in patients with 2 and 3 degrees of arterial hypertension.It was found that therapy based on the combinations of losartan with hydrochlorothiazide and lisinopril with hydrochlorothiazide led to the significantly greater cSBP reduction compared with therapy based on bisoprolol and hydrochlorothiazide. In the group of beta-blocker based combination therapy we observed a significant increase of augmentation index compared with other regimens of therapy. In groups of ARBs and ACE inhibitors based combinations the improvement of vascular stiffness was significantly grater.

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