Rudenka K. Studying the effect of neurotrophic factors of embryonic nervous tissue on the morphological and functional state of the inner ear of experimental animals with experimentally induced sensorineural hearing loss

The dissertation is devoted to the study of the influence of neurotrophic factors on the morphological and functional state of the inner ear of guinea pigs in an experimentally induced sensorineural hearing loss deafness caused by antibiotics of the aminoglycoside series. The dissertation is based on the complex comparison of research of the morphological state and functional changes of the internal ear structures of the experimental animals when the drug Trofin was administered in various ways (intramuscularly, intratympanicly, and intraperitoneally) for 7 and 14 days both sequentially and after 14 days of gentamicin injections. Our study allowed, using an objective method of examination, to study the effect of the Trofin on the normal structures of the inner ear of guinea pigs, as well as its protective and therapeutic effect in the case of gentamicin ototoxicosis at different routes of administration and for different periods of use. It turned out that the Trofin does not have a statistically significant effect on the OAE's response to healthy guinea pigs at different routes of administration and in terms of use. Consequently, it does not damage the structure of the inner ear and is safe to use. According to our observations, Trofin has a tread effect and sufficient effective therapeutic effect in the case of gentamicin damage to the receptor department of the auditory guinea pig analyzer. At the same time, somewhat higher efficacy takes place with intramuscular paranalysis of the Trofin for 14 days. Our research provides the basis for developing new ways of treating and preventing damage to the receptor department of the auditory analyzer and introducing them into clinical practice. These studies are laboratory evidence for the further clinical testing of the possibility of using Trofin in the integrated therapy of patients with sensorineural hearing loss deafness.