Lysenko M. Efficiency of modified method treatment of keratoconus

Keratoconus is a chronic non-inflammatory progressive, stage disease which refer to primary keratoectatic disorders of the eye. It leads to early disability and blindness, especially in persons of working age. Treatment of keratoconus is extremely difficult as there is no evident knowledge about the mechanisms of the progression of the process and the modern diagnostic technologies are imperfectly used. As a rule, the benefits are given to the surgical methods of treatment. In spite of the considerable potential of layered techniques for keratoplasty that have undergone significant development over the past two decades, penetrating keratoplasty (PKP) remains the "gold standard" in the treatment of corneal pathology. At the same time, issues of donor tissue shortage remain relevant and unresolved. Results of the research On the basis of the conducted studies, it was noted that the layer of endothelial cells on the corneal graft, visualized with ex vivo confocal microscopy, has a different tone of gray color on the different cadaveric eyes (the reflectivity of the endothelial cell cytoplasm, which is independent of endothelial cells dencity or central corneal thicknes). Accordingly, images of the layer of endothelial cells of different corneal graft have different configurations of tone histograms in grayscale grayscale on a scale from "0" (black) to "255" (white). For the quantitative assessment of the endothelial reflectivity of the corneal graft, the concept of "RCCEC" (reflectivity coeffitient of corneal endothelial cells) was suggested, representing the value of the distribution mode of gray pixels on the tonal histogram of the image of the endothelial layer of corneal graft obtained with ex vivo confocal microscopy.