Kuz U. Morphological and functional changes of the lungs due to early stabilization of fractures because of multiple bone trauma and ways of their correction

The aim of study was to found out the features of morphologic and functional changes of the respiratory department of lungs due to multiple skeletal trauma and intramedullary osteosynthesis. Due to multiple skeletal trauma changes in the respiratory department of the lungs were detected already during the first 24 h of the experiment. The most pronounced damage was found on the 72 h. Multiple skeletal trauma also was accompanied by an intensification of lipoperoxidation processes already during the first 6 h, subsequently it leads to increase of systemic inflammatory response while 72 h, internal toxicity while 168 hours and immunosuppression. The intramedullary osteosynthesis group had more severe damage of the submicroscopic structure all components of the respiratory department of lungs than multiple skeletal trauma. The pronounced destructive changes were observed in components of the respiratory department of lungs while 24 h. The intracellular swelling was still defined while 72 h, but less than on the previous stage. The intramedullary osteosynthesis is accompanied by a peak increase while 24 72 h of lipid peroxidation, systemic inflammatory response, internal toxicity. The lipin administration enhances a decrease changes in the respiratory department and improvement of rheological properties blood. The components of the respiratory department were better saved. Lipin correction helps to decrease the negative systemic effect of the intramedullary osteosynthesis on the background of multiple skeletal trauma due to stabilization of lipoperoxidation processes, inflammatory response and internal toxicity. Consider data of morphological and biochemical studies, lipin administration due to multiple skeletal trauma is effective during the first 24 h. The study broadening and deepening the information about morphologic and functional changes in the respiratory department of the lung due to early instrumentation of the hip bone fractures on background of multiple trauma. These data may be theoretical base to use lipin for other their correction. Key words: lungs, respiratory department, multiple skeletal trauma, osteosynthesis, lipin. Branch - Medicine.