Savka S. Structural and dynamic characteristics of non-psychotic mental disorders associated with rheumatoid arthritis

The thesis is devoted to the problem of comorbid nonpsychotic mental disorders in rheumatoid arthritis, development of criteria for diagnosis and complex (psychopharmacological and psychotherapeutic) correction of mental disorders associated with rheumatoid arthritis. The study was based on examination of 160 people, 120 of them are patients with nonpsychotic mental disorders (NMD) and rheumatoid arthritis (RA), namely 55 patients with the duration of the RA disease up to 5 years (BG I), and 65 patients with the duration of the RA disease from 5 to 10 years (BG ІІ), while other 40 persons belonging to the general population (CG). Based on the study of clinical-psychopathological, patho-psychological and psychosocial features of formation of the NMD associated with the RA, the author has systematized the clinical and diagnostic criteria of the NMD against the background of the RA process, depending on the duration of the disease on the symptomatic, syndromic, and nosological levels. Patients with the RA, the most often suffer from the following NMD: a depressive disorder – 35.0% of patients, anxiety disorder – 21.7%, the disorder of adaptation – 12.5%, emotionally labile (asthenic) disorder – 19.2%, anxiety-phobic disorder – 11.6%. With the extension of the duration of the RA, increases the number of people with depression disorder (from 18.2% to 49.2%, p<0.01), anxiety disorder (from 16.3% to 26.1%, p<0.05) and decreases the number of people with anxiety-phobic disorder (from 20.0% to 4, 7%, p<0.01), emotionally labile (asthenic) disorder (from 27.3% to 12.3%, p <0.05) and disorder of adaptation (from 18.2% to 7.7%, p<0.05). As a result of the conducted clinical and psychopathological study, the program of complex (psychopharmacological and psychotherapeutic) correction of the NMD associated with the RA has been scientifically substantiated, developed and tested.