Slipkan A. Synthesis and properties nanoparticles of zirconium phosphate loaded with dirhenium(III) complexes

The thesis is devoted to the synthesis, construction of the structure and properties of nanoparticles of zirconium phosphate loaded with representatives of dirhenium(III) complexes of all structural types. The changes that took place with dirhenium(III) complexes as a result of the intercalation process in time were observed using electron absorbtion spectroscopy. In electron absorption spectra of reaction solutions, the processes characteristic of changing the ligand environment of dirhenium(III) complexes were fixed. In addition, the gradual decrease in the intensity of the characteristic absorption band of complexes indicates that it is coordinated with zirconium phosphate via Oxygen phosphate groups of nanoparticles directed on both sides of the plane of the nanoparticle. Shown that nanoparticles have the correct hexagonal shape, with a diameter of 100-200 nm and a height of 10-50 nm. In addition, individual particles can form agglomerates up to 1 μm, as shown by the low ζ-potential of nanoparticles in aqueous suspensions. Was found that for samples with molar ratio of substance / zirconium phosphate 1/30, the total content of the rhenium(III) compound was 10-12% of the total sample mass. For the molar ratio of 1/5 this percentage was 25-39%, depending on the structural type of dirhenium(III) complexes. The release complexes occurs at pH = 4.5, which simulates the pH of the tumor cell medium, and, to a lesser extent, in a medium simulating human plasma of pH = 7.4. In addition, these findings give grounds for asserting the possibility of a pH-targeted delivery in the body of a patient with cancer pathology.