Nizhynska-Astapenko Z. Imbalanse of blood gas composition in diabetic ketoacidosis and ways of its correction.

Object of study: diabetic ketoacidosis (DKA). Aim of the study: to optimize the diagnosis and treatment of patients with diabetic ketoacidosis on the basis of studying the patterns of changes in blood gas composition and acid-base balance under conditions of diabetic ketosis and ketoacidosis of different severity and the use of antihypoxants in the complex treatment of acute complications. Research methods and equipment: general clinical, instrumental, biochemical, potentiometric and statistical; D-10 Bio-Rad analyzer, automatic Easy-Blood Gas analyzer. Theoretical and practical results: studies have shown that disorders of blood gas composition are determined at the stage of diabetic ketosis and progress in ketoacidosis. The revealed changes in blood gas composition are corrected by etiopathogenetic basic therapy. The antihypoxant effect of actovegin and cytoflavin by the simultaneous determination of the gas composition of arterial and venous blood was studied. Novelty: found that the direction of violations of blood gas composition in ketosis is similar to changes in DKA. The peculiarities of gas exchange and acid-base disorders of blood changes in different clinical variants of DKA course have been determined for the first time. The daily dose of insulin required for the treatment of patients with DKA in various clinical variants of its course has been determined. The expediency of using antihypoxants in complex therapy of DKA based on the results of determination of blood gas composition is substantiated. Degree of implementation: the results of the research have been incorporated into the clinical practice of medical institutions of regional centers of Ukraine and are used in the educational process of higher educational institutions. Areas of use: endocrinology.