Paiuk O. Synthesis and properties of surface-active block/comb-like copolymers based on PEG- and fluorine-containing methacrylates

The thesis is devoted to synthesis of novel surface-active copolymers of block/comb-like structure by usage of comb-like copolymers with side polyethylene glycol or fluoroalkyl chains and terminal reactive fragments of isopropyl benzene derivatives. Such telechelic comb-like polymers with terminal functional fragment obtained by radical polymerization of appropriate methacrylates in presence of functional peroxy-, epoxy- or amine-containing isopropyle derivatives as chain transfer agents. Obtained comb-like polymers with a terminal reactive group (peroxide-, epoxide- or amine) successfully used as macromolecules-precursors for synthesis of copolymers with complex architecture. Thus, the type of terminal group in telechelic comb-like polymer composition determined grafting mechanism of successive polymeric block: radical or additive. Kinetic peculiarities of block/comb-like copolymers synthesis established for each polymerization steps. Colloidal-chemical properties of amphiphilic comb-like copolymers with PEG-side chains, block-copolymers based on them, and block-copolymers with hydrophobic fluorine-containing block were studied. The influence of macromolecular structure (such as the lengths of side and backbone chains, their microstructure) and complex formation with carboxylic acids on colloidal-chemical properties PEG-containing comb-like polymers were established. Colloidal-chemical properties of amphiphilic block-/comb-like copolymers controlled by varying lengths of fluorine- or PEG-containing side chains, comb-like and linear blocks. Synthesized block-/comb-like copolymers can form intermolecular complexes with other substances of natural and / or synthetic origin, such as nucleic acids, lysozyme, etc. Synthesized comb-like and block/comb-like macromolecules are effective carriers of anticancer drugs, antimicrobial proteins, nucleic acids and fluorescence-labeled oligonucleotides in composition of micellar delivery systems. It can be used for cancer treatment, genetic engineering, biological objects labeling and imaging.