Chebotar O. Justification of the prevention and treatment of sialosis in patients with hypothyroidism

The dissertation is devoted to the study of changes in salivary glands and biochemical composition of oral fluid in patients with hypothyroidism in order to prevent, timely diagnosis and treatment of sialosis that occurs on the background of hypothyroidism. The thesis is devoted to the study of changes in the salivary glands and the biochemical composition of the oral fluid in patients with hypothyroidism with the aim of preventing, timely diagnosis and treatment of sialosis. A study of the salivary gland lesion on the background of hypothyroidism established that all patients have sialosis at different stages of the development of pathology: 12.8% of patients had an initial stage, 67.5% had a stage of clinical manifestations, and 19.7% had a late stage, and also observed xerostomia, impaired excretion, changes in the consistency and crystallization of the oral fluid. The use of a complex of vitamins, enzymes in combination with stimulation of the parasympathetic nervous system with pilocarpine and local salivation mechanisms allows eliminating inflammatory processes and restoring secretory processes suppressed by pathology in the salivary glands of experimental rats with hypothyroidism. With sialosis with hypothyroidism in the oral fluid, crystallization processes change.We found that the crystalloscopic method for determining various types of oral microcrystallization can be used to diagnose and determine the effectiveness of the treatment of sialosis in patients with hypothyroidism. A method has been developed for the treatment of sialosis with the use of a bioregulator, proteolytic enzymes, a vitamin complex for general treatment, a solution of carbacholine and ultraphonophoresis with propolis oil as a local treatment. Also, biochemical studies have found an increase in α-amylase by 2.5 times, catalase by 1.5 times, lysozyme 2.6 times, sIgA 1.6 times and a decrease in alkaline phosphatase activity 2,3 times in the oral cavity in patients with hypothyroidism. The clinical effectiveness of the developed treatment and prophylactic complex in the treatment of sialosis in patients with hypothyroidism has been proved by a 1.6-fold decrease in the amount of total protein, a 1.5-fold decrease in the oral fluid viscosity and a 2-fold increase in the amount of saliva secretion, a reduction in the number of complaints after a week of treatment, and the absence of relapses during the study period compared to standard treatment methods.