Cherpak M. Comparative assessment of the effectiveness of calcium-phosphate alloplastic materials and biopolymer composite of polylactide with hydroxyapatite for osteoplasty of jaw defects

The composition is substantiated and the technology of obtaining biopolymer osteoplastic composite (BPC) in the form of granules on the basis of polylactide (PL), artificial hydroxyapatite powder (HP) and beta-tricalcium phosphate (β-TCP), which differs from the existing synthetic osteoplastic materials by specific mineral-polymer structure, controllability of its temporality, is controlled. conditions for restoration of the lost volume of bone tissue in the defect, to shorten the time of osteo-regeneration, to optimize the processes of differentiation and maturation of structures the rhino bone with the restoration of its complete morphological structure. The biological indifference of the BPC was confirmed by the absence of toxic effects, cytotoxic, irritant and sensitizing effects. According to the results of the studies, the terms of bone formation during application for BPC osteplasty were faster than in the cases of Kergap bio-ceramics (Biomin-HT) and especially in comparison with the control. BPC provides effective filling of the volume of the bone defect, reproducing its shape and anatomical surface, does not cause harmful effects on the surrounding tissues and has a pronounced osteoconductive potential.