Nevmerzhytska L. Alcohol septal ablation for hypertrophic obstructive cardiomyopathy treatment

This dissertation was designed to assess the results of alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy (HOCM) based on analysis of hemodynamic, morphometry, electrical activity of the heart and functional status of the patients. Materials. In current study 129 patients (pts) with HOCM had ASA procedure performed in Amosov National Institute of Cardiovascular Surgery from 2009 to 2018. Morphological changes in myocardium of interventricular septum, parameters of intracardiac hemodynamic, morphometry, electrical heart activity and functional status of the patients before and after ASA procedure were assessed in current study. Also, influence of obesity, coronary artery disease and arterial hypertension on results of ASA was analysed. Moreover, rate and reasons of unsatisfactory results after ASA in immediate and long-term follow-up were analysed. ASA should remain the alternative methods of HOCM treatment especially when contraindications to open heart surgery or/and necessity of concomitant structural cardiac abnormality repair exists, or in institutions where open heart surgery is not available.