Halkevych M. Features of the course of the acute coronary syndrome in the settings of type 2 diabetes mellitus and other risk factors for ischemic heart disease

The dissertation is devoted to the improvement of the diagnosis and treatment of acute coronary syndrome (ACS) by studying the impact of individual ischemic heart disease (IHD) risk factors and their combination on the development and course of ACS during the inpatient phase of treatment. The relationship between the clinical course of ACS and the development of cardiovascular complications (acute or chronic heart failure, acute left ventricular aneurysm, recurrent acute myocardial infarction, rhythm and conductivity disturbances) and the levels of stimulating growth factor (ST2) and N-terminal pro-brain natriuretic peptide (NT-proBNP) biomarkers were clarified and their prognostic value for the IHD course was determined. Additional data on the effects of primary coronary stenting on the occurrence of early complications of the disease during the inpatient period were obtained. Scientific data on the influence of type 2 diabetes mellitus (DM) and other risk factors for CHD on the morpho-functional state of platelets (PLTs) as a primary link in hemostasis have been expanded using electron microscopic studies. A diagnostic technique of PLT resistance to antiplatelet drugs in IHD patients in the presence of type 2 DM with the help of their electron microscopic examination was developed.