Savytska L. Role of renal functional reserve, uric acid and magnesium levels in the progression of chronic kidney disease.

The object of study: diagnostic markers of CKD stages I-III progressive course on the background of arterial hypertension, diabetes mellitus, their combination, primary gout, urinary tract infection, chronic glomerulonephritis. The aim of the study: to increase the diagnostic efficiency and to develop a diagnostic tool to identify patients at risk of CKD stages I-III progression, regardless of the reasons for its development, by examining the renal functional reserve, serum uric acid and magnesium levels. Research methods: general clinical, anthropometric, laboratory, statistical. The scientific novelty of the obtained results: for the first time, the modified test with water-salt load was used as a diagnostic tool to identify patients at risk of CKD stage I-III progression and the diagnostic criteria were verified: a decrease in uric acid concentration less than 5 μmol/l and a decrease in urinary creatinine more than 2 mmol/l. For the first time, a risk group was identified: it includes patients with one or two of diagnostic criteria The scientific data on the state of the renal functional reserve have been supplemented: direct correlation of renal reserve with serum uric acid average level during a year and inverse correlation with pulse pressure was established. Scientific data on the clinical significance of optimal serum magnesium levels in patients with CKD stage III to maintain water-excretory and tubular function were further developed.