The dissertation is devoted to increasing the effectiveness of the treatment of chronic generalized periodontitis by using the complex of α-tocopherol acetate, ascorbic acid, retinol acetate and selenium preparations, which affects different elements of antioxidant defence.
At the beginning of treatment in the oral fluid of patients of all three groups, there was a decrease in the level of superoxide dismutase (SOD), glutathione peroxidase (GSR) and catalase, the level of malondialdehyde (MDA) was significantly increased.
After the treatment of the patients of the first group, the changes in indicators were insignificant, so the level of SOD remained 0.21 ± 0.01, the level of GSR - 24.42 ± 0.36, the level of catalase 0.10 ± 0.01, the level of MDA also changed slightly and reached 0.48 ± 0.02. A year later, these indicators of antioxidant protection also have not changed much. SOD level – 0.20 ± 0.01, GSR – 24.21 ± 0.32, catalase level – 0.09 ± 0.01, MDA level was 0.49 ± 0.01.
In the second group, the SOD content in the oral fluid increased and was 0.29 ± 0.01, almost reaching the norm, the GSR level also changed to 36.74 ± 0.32, the catalase level – 0.17 ± 0.01, the MDA content slightly decreased to 0.21 ± 0.01. After a year, these indicators have changed. The SOD level decreased to 0.28 ± 0.24, the GSR content almost returned to the initial parameters – 25.66 ± 0.24, the catalase level decreased to 0.10 ± 0.01, and the MDA level increased to 0.49 ± 0,01.
After the combined therapy of the patients of the third clinical group, the SOD content in the oral fluid was 0.33 ± 0.02, the GSR level also reached normal degree – 43.28 ± 0.26, the catalase content increased to 0.19 ± 0.01, and the MDA level decreased to 0.23 ± 0.01. A year later, we observed the following clinical pattern.
The content of SOD in the oral fluid was 0.32 ± 0.01 and remained within the normal range, the content of GSR remained almost unchanged and was 42.97 ± 0.32, the catalase decreased slightly to 42.97 ± 0.32 and remained within the norm, and the MDA level was 0.24 ± 0.02, also without the significant changes.
After the treatment, the indicators of antioxidant protection in the oral fluid remained unchanged for all of the patients of the comparison group. For patients of the second group, the indicators of antioxidant protection after the treatment changed and reached physiological parameters, but after a year their level returned to the initial values, which was reflected in the clinical picture.
For all patients belonging to the third group, the indicators of antioxidant protection reached normal values and after a year remained practically unchanged, the clinical pattern of the course of chronic generalized periodontitis also corresponded to the state of indicators of antioxidant protection. Thus, for all patients of the third clinical group, we achieved not only an improvement in the state of the periodontal tissues, but also a stable remission. This indicates the effectiveness of our proposed treatment scheme for chronic generalized periodontitis.
