Nedoborenko V. Clinical and immunological features of systemic inflammation in women with obesity in association with iron deficiency anemia, and development of a method for their comprehensive treatment.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0420U101914

Thesis Registration Form

0420U101914.pdf

Applicant for

Specialization

  • 14.01.02 - Внутрішні хвороби

22-10-2020

Specialized Academic Board

Д 44.601.02

Ukrainian medical stomatological Academy

Essay

The research focuses on the features of systemic inflammation in women with iron deficiency anemia in association with obesity by studying the relationship between iron metabolism and pro-inflammatory cytokines to develop a method for their comprehensive treatment. In obese women, the development of iron deficiency and, accordingly, IDA causes a decrease in the level of systemic inflammatory response (decrease in the content of IL-6 and high-sensitive CRP in the serum). Restoration of iron metabolism with iron sulfate (II) caused an increase in systemic inflammation in both women with normal body weight and obesity. The inclusion of quercetin in the comprehensive therapy of women with IDA and obesity prevents an increase in the level of systemic inflammation when taking iron (II). The possible association of systemic inflammation, hepcidin and NF-kB as the central link in proinflammatory signals of regulatory genes has been demonstrated.

Read more

Files

autoreferat-aref.doc

dis.doc

Similar theses

0424U000059

Khrystyna Mykolaivna M. Fedorovych

Clinical and laboratory features of the cardiovascular status of patients with rheumatoid arthritis and optimization of the principles of its correction.

0523U100054

Strilchuk Larysa Mykolaivna

Autonomic viscero-visceral cardioneuropathy in patients with biliary disorders: prevalence, mechanisms, pathogenesis, clinical polymorphism, and treatment approaches

0523U100045

Didenko Volodymyr Izotovych

Chronic diffuse liver diseases: etiological, structural and clinical-biochemical aspects of the formation of fibrous changes (clinical-experimental study)

0422U100009

Bazhenova Nataliia Mykhailivna

The state of platelet-plasma hemostasis in patients with arterial hypertension in combination with obesity and nonalcoholic fatty liver disease

0422U100010

Tkachyshyn Oleksandr Volodymyrovych

Features of the course of essential hypertension complicated with hemorrhagic stroke, and changes in the hemostasis system during the treatment