Manska K. Hormonal, metabolic and behavioral features of the primary obesity in young women.

The dissertation work is devoted to the topical issue of endocrinology, namely, the deepening of the modern scientific understanding of the role of melatonin and serotonin in the development of behavioral and metabolic aspects of primary obesity (OB) in young women and the verification of prognostically significant criteria for early development of a cluster of metabolic disorders, optimization of the existing strategy for the prevention of comorbid OB pathologies in this category of the population. The possible indirect protective role of increasing daily melatonin secretion in the development of insulin resistance in young women with an inverted circadian rhythm of hormone secretion is shown. It was registered that women with primary obesity in comparison with those surveyed with overweight have more distinct eating disorders of restrictive and external types. Young women with abdominal obesity, in contrast to those with a normal waist circumference, have significant eating disorders according to emociogenic and external types; with severe abdominal obesity – according to emociogenic, external and restrictive types. It is proved that an additional criterion for the risk of insulin resistance in the female urban population of young age can be considered the presence of eating disorders, primarily of a restrictive type. It was found that for the assessment of a young female representative of the Ukrainian population with primary OB risk of developing metabolic complications, the most informative is a comprehensive determination of such parameters as waist circumference, relative fat mass, atherogenicity coefficient, index HOMA, and the level of the daily fraction of urinary excretion of the metabolite melatonin 6-sulfatoxymelatonin. Mathematical models are constructed that allow estimating the risk of developing metabolic syndrome in women of this category based on the levels of the above indicators.