Masud A. Fundamentals of chemistry and technology of 6-methyluracil-5-sulfochloride and products based on it

The dissertation work is devoted to the improvement of the technology for obtaining 6-methyluracil-5-sulfochloride, the development of methods for the synthesis of compounds based on 6-methyluracil-5-sulfochloride, the elucidation of the main regularities of their chemical behavior, physicochemical properties and the prediction of possible biological activity. The interaction of 6-methyluracil-5-sulfochloride with oxides and hydroxides of some metals (II) with the formation of salts of their cations was studied. Esters were synthesized with alcohols and phenols. It was found that with lengthening of the carbon chain, the rate of esterification decreases. With primary and secondary aliphatic and aromatic amines in an inert organic solvent, interaction with methyluracilsulfochloridewas carried out. A number of sulfonamides were synthesized by this reaction, most of which are not described in the literature. Based on the relationship between structure and biological activity, taking into account the specific features, as well as the molecular mechanisms of action of 6-methyluracil derivatives, a chemical modification is proposed in order to reduce toxicity and impart new biological properties. These can be chemical compounds consisting of N-aryl and N-alkylsulfonamides, as well as sulfoesters obtained on the basis of a 5-substituted-6-methyluracil radical. Prediction of the biological activity of new compounds was carried out using the Prediction of Activity spectra for Sabstances (PASS) program.