Object is the regularities of influence of different doses and ratios of mineral fertilizers on the change of humus content, agrochemical, physicochemical parameters of podzolized chernozem in the field crop rotation, crop yield and product quality. Purpose is to evaluate the evolutionary direction of the nature of changes, the intensity of the main properties transformation, regimes of podzolized heavy loam chernozem of the Right-Bank Forest-Steppe at different doses and ratios of mineral fertilizers, their effectiveness in short-term field crop rotation against the background of embedding tailings into the soil and the development of a fertilizer system to restore soil fertility and obtain stable yields. The methods – field method, laboratory method, balance method, calculation and comparison method, mathematical and statistical method. Theoretical results – it is established that the accumulation of humus in the soil is aquivalent to anthropogenic load in the form of systematic application of mineral fertilizers, primarily the nitrogen ones. It is proved that the process of reproducing the podzolized chernozem fertility is largely determined by the doses of nitrogen fertilizers, and then the phosphatic fertilisers. If the dose of potassium fertilizers is halved after the second rotation of the four-field crop rotation (winter wheat, maize, spring barley, soybeans), the content of humus, nitrogen of easily hydrolyzed compounds, mobile compounds of phosphorus and potassium in the soil is preserved at the initial level. The indices of absolute and relative depletion of the main nutrients with winter wheat, spring barley, maize, soybeans depending on the fertilizer are specified. The methodology of agrochemical research on optimization of the fertilizer system in field crop rotation using the complex assessment index was further developed. Practical results – the system of fertilizer application on podzolized heavy loam chernozem of the Right-bank Forest-Steppe is improved with substantiation of possible reduction of fertilizer doses that provides average annual introduction of mineral fertilizers in a dose of N110P60K4 against the background of embedding the non-commodity part of yield into the soil, including for winter wheat – N150P60K40, maize – N160P60K55, spring barley – N70P60K35 and soybeans – N60P60K30. Novelty lies in the theoretical justification of ways to optimize mineral nutrition of plants with long-term use of different doses and ratios of mineral fertilizers in short-term field crop rotation against the background of embedding the non-commodity part of yield into the soil, their effect on podzolized chernozem fertility is revealed; the fertilizer systems aimed at increasing yields and quality of agricultural products are developed. It is established that the accumulation of humus in the soil is equivalent to the anthropogenic load in the form of systematic application of mineral fertilizers, primarily the nitrogen ones. Under the application of N110P60K40 per 1 ha of crop rotation area against the background of leaving the non-commodity part of crop in the field provides an intensive balance of basic nutrients with a rate of 105–127%. Degree of application – the results of the research were positively assessed and implemented in SERH “Salivonkivske” of the National Academy of Agrarian Sciences of Ukraine located in Hrebinka, Vasylkiv district, Kyiv region on the area of 2547.8 hectares and Agricultural LLC “Rodyna”, located in village Synky, Blahovishchenske district, Kirovohrad region on the area of 1200 hectares. The field is agriculture.