Romanyshyn N. Improving the Effectiveness of Pharmacotherapy for Stable Coronary Artery Disease After Intravascular Coronary Angioplasty.

The dissertation is devoted to improving treatment effectiveness for 120 patients with chronic coronary artery disease, heart failure with preserved left ventricular ejection fraction after percutaneous coronary revascularization through the prediction of disease progression and the development of the most appropriate treatment for such patients. The advantages of using sinus node if-channel inhibitor – ivabradine against the background of standard therapy for 12 months have been proven. The dissertation is devoted to the study of the predictors for the development and progression of stable coronary artery disease depending on the number of the affected coronary arteries based on clinical manifestations, functional capacity of the left ventricle, the state of coronary and myocardial reserves, the concentration of brain natriuretic peptide, endothelin-1, tumor necrosis factor-alpha, C-reactive protein and plasma lipid profile in 120 patients with stable coronary artery disease after coronary stenting. Practical guidelines for predicting the clinical course and determining the algorithm for treatment of stable coronary artery disease after coronary artery stenting have been formulated; the effectiveness of treatment and its importance in preventing complications have been presented. Thus, to slow down heart failure progression and to reduce the occurrence of new cardiac events after percutaneous coronary intervention, long-term use of sinus node if-channel inhibitor should be added to background therapy for coronary artery disease. Key words: Stable Coronary Artery Disease, Coronary Angiography, Stenting, Ivabradine, Pharmacotherapy. Branch – Medicine.