Kostiukova D. Optimization of complex clinical and electrophysiological diagnostics and treatment of paroxysmal events in preterm infants

The dissertation substantiates the early clinical and electrophysiological diagnostics and timely treatment of paroxysmal events in order to improve the survival and quality of life of premature infants. The nature of perinatal pathology associated with premature birth is analyzed in detail and the clinical characteristics of paroxysmal events in preterm infants of different gestational ages are given. Prognostically unfavorable electrophysiological characteristics were determined, the frequency of electroclinical and electrographic seizures, sleep-dependent respiratory disorders in children of different gestational and postmenstrual ages was studied. Differentiated therapy of paroxysmal disorders of epileptic and non-epileptic genesis in preterm infants of observation groups has been performed. An integration system of complex neuromonitoring was created and neurophysiological management of paroxysmal events in preterm infants was implemented. Introduced of diagnostics algorithms, treatment and recommendations for monitoring of paroxysmal events using electrophysiological diagnostic methods - polysomnography, amplitude-integrated electroencephalography, standard electroencephalography; questionnaires and identification of high-risk groups for the development of sudden infant death syndrome, apparent life-threatening events, nervous system damages with the formation of seizure syndrome and carrying out a follow-up observation with elements of the system of early intervention. Keywords: preterm infants, paroxysmal epileptic and non-epileptic events, sleep-related breathing disorders, electrophysiological diagnostics, electroencephalography, polysomnography, follow-up observation.