Yatsulchak G. Technological basics of composite hydrogel films formation from polyvinylpyrrolidone copolymers and polycaproamide

The dissertation is devoted to solving an important scientific and technical problem, namely, the development of technological basics of composite hydrogel films formation via physical modification by a polycaproamide with polyvinylpyrrolidone (PA-6/PVP) mixture, which is a liquid-crosslinked copolymer of (polyvinylpyrrolidone) PVP and 2-hydroxyethyl methacrylate (2-НEMA), and with determination of physico-mechanical and physico-chemical properties typical of membranes. It was found that polyvinylpyrrolidone with a molecular weight of 12•103 g/mol in the strengthening layer of PA-6/PVP and with a molecular weight of 360•103 g/mol in the substrate membrane promotes the formation of a composite hydrogel membrane of high strength. The formation of a strengthening near-surface layer based on PA-6/PVP composite membranes was confirmed by scanning electron microscopy and X-ray structure analysis.. It was found that hydrogel films of high strength modified with a thin layer of the PA-6/PVP mixture from a formic acid solution can be used in medicine and pharmaceutics.The suitability of the formed membranes for the osmosis process, for the clarification of "Gentamicin sulfate" and "Korglikon" drugs.