Klishch O. Clinical and diagnostic value of determining the indicators of oxygen-dependent metabolism and oxidative stress in predicting the outcome of perinatal pathology in extremely preterm infants

The dissertation presents the issues of predicting the unfavorable course of perinatal pathology in extremely preterm infants by studying the clinical and anamnestic features, indicators of oxygen-dependent metabolism and oxidative stress. Study has shown that gestational age and birth weight are important factors associated with the early outcomes of preterm infants with gestational age less than 32 weeks. Extremely low birth weight and gestational age of 22-32 weeks are closely related to the morbidity and mortality in this category of patients. The survival rate of preterm infants increases with the increasing gestational age (more than 28 weeks of gestation) and birth weight (more than 1000 g), and is associated with gender profile). Evaluation of the oxidative stress markers in the study groups revealed its statistically significant difference depending on the birth weight. Comparison of the oxidative stress indicators in infants with unfavorable and favorable outcomes in the early neonatal period showed a significant increased levels of 8-isoprostane, lipid hydroperoxides, TBA-active products of lipoperoxidation and a significant decrease of catalase and superoxide dismutase activity in infants with unfavorable prognosis. The received data also confirm the sensitivity of cellular energy status indicators (lactate, pyruvate, lactate / pyruvate ratio, NAD+/NADN) in the objective reflection of the unfavorable outcomes for survival of the preterm infants in the early neonatal period.