Teslenko T. Improvement of diagnosis and prognosis of cardiovascular disorders in newborns with seizure syndrome in early neonatal period

The thesis is devoted to improvement of diagnosis and prognosis of cardiovascular disorders in newborns with seizure syndrome by conducting of clinical, laboratory and instrumental comparisons among conditions of central and cerebral hemodynamics, results of electrocardiography and amplitude-integrated electroencephalography. It was found that the most unfavorable indicators for the development of cardiovascular disorders in newborns with subclinical and clinical seizures according to instrumental examination (Doppler echocardiography) are reduction of systolic (cardiac) index and ejection fraction of the heart. Predictors for cardiovascular disorders were identified: duration of P wave, QRS complex, QT interval and Sokolow-Lyon index according to electrocardiography; resistance index of anterior and middle cerebral arteries according to Doppler neurosonography; increase of the maximum and decrease of the minimum amplitude according to amplitude-integrated electroencephalography, signs of metabolic acidosis in umbilical cord blood according to arterial blood gases test. Developed prognostic model allows with 84 % of reliability to predict risk of cardiovascular disorders in newborns in order to individualize further supervision and management of the newborn in practice of pediatrician-neonatologist.