Voronenko O. Prognostic influence of type 2 diabetes mellitus on the course and treatment of chronic heart failure in patients after implantation of a pacemaker

In the dissertation the clinical and pathogenetic substantiation of prognostic influence of type 2 diabetes mellitus on the course of chronic heart failure, pathogenetic features and treatment tactics in patients with implantation of a permanent pacemaker are given. The obtained results show that in of progression of comorbid pathology, a significant involvement of remodeling of the morphofunctional state of the heart muscle is determined. Type 2 diabetes had a significant effect on the increase in left ventricular volume and size in the examined patients. It was determined that the functional parameters of the left ventricle correlate with glucose metabolism indices, which determines the effect of glucose on the contractile myocardium of the ventricles. The probability of a response to the implantation of pacemaker in patients with concomitant type 2 diabetes depends on the degree of preservation of the left ventricular ejection fraction, the presence in the therapeutic regimen of β-blockers and hypoglycemic drugs (dapagliflozin).