Skalchuk V. Eimeriosis-cryptosporidiosis invasion of calves (spread, pathogenesis, treatment)

The dissertation presents new data on the prevalence of mixed course of eimeriosis and cryptosporidiosis of calves in the farms of Odessa and Vinnytsia regions of Ukraine depending on the system of keeping, their age and seasonal dynamics. In the south of Odesa oblast, the incidence of calves with cryptosporidia was 60.9 %, and in the north of Odesa and Vinnytsia oblasts cryptosporidiosis dominated and in association with eimeriosis ‒ 30.5 % and 29.3 %, respectively. The influence of eimerias and cryptosporidia on morphological and biochemical parameters of calves' blood was studied. The therapeutic efficacy of brovitacoccid, tolcoccid 2.5 % and amprolev-plus in the mixed course of eimeriosis and cryptosporidiosis of calves was determined and their influence on morphological, biochemical and immunological parameters of blood was clarified. The drug amprolev-plus with an efficiency of 90 % for eimeriosis and 100 % for cryptosporidiosis of calves. After the use of the drug amprolev-plus morphological and biochemical parameters of the blood of calves in the mixed course of eimeriosis and cryptosporidiosis approached the control values at 15 days, while with the use of brovitacoccid ‒ at 15-25 days. The disinvasive effect of in vitro solutions of bi-des and brovadez-plus of different concentrations on the process of sporulation oocysts of calves was determined. In vitro experimental studies have shown that the drug brovadez-plus in 3 and 3.5 % concentrations at exposures of 5 and 8 hours has a high level of disinvasive properties against oocysts of calves. In 96.8±2.1 % and 99.1±2.4 % oocysts of eimeria, the process of sporogony was not registered.