Zubach O. Risk factors, methods of its prognosing and mortality of patients with proximal hip fractures

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0421U103295

Applicant for

Specialization

  • 14.01.21 - Травматологія та ортопедія

06-04-2021

Specialized Academic Board

Д 11.600.04

Donetsk National Medical University

Essay

The object of the research – proximal hip fractures (intra- and extraarticular) in the man and women population, aged 40 years old and more; purpose of study – to increase the effectiveness of prevention and treatment of the proximal hip fractures on the basis of studying risk factors, methods of its prognosis, mortality and survival of patients; methods – patient’s surveys (regarding previous fractures (presence, quantity and localization, year of occurrence, clinical and life prognosis), the presence of concomitant diseases, features of menstrual function in women, level of physical activity, surveys using scales on the expression of pain syndrome (digital rating scale), quality of life (EuroQol-5D) and 10-year probability of the basics of osteoporotic fractures (FRAX), objective examination of patients with assessment of orthopedic status and measurement of basic anthropometric parameters of the body, instrumental methods (X-rays of hip joints, two-photonic X-ray absorptiometry for identification of the mineral density of bone tissue and conducting structural analysis of the femoral bone), laboratory methods, statistical analysis; novelty –firstly in Ukraine were identified indicators of long-term (ten-year) mortality and survival in patients with proximal hip fractures; based on comparative analysis of short-term mortality indicators (up to 2 years after the fracture) and the survival rate of patients with proximal hip fractures over a 10-year period, the main factors influencing these indicators (age and sex of patients, the fact of hospitalization, surgical treatment of the fracture) were identified; supplemented data about mineral density of bone tissue of different parts of the skeleton in persons with proximal hip fractures in different times after the fracture and determined the partial component of osteoporosis and osteopenia; new knowledge about the level of vitamin D in the blood of patients with proximal hip fractures and certain proportion of its deficiency and insufficiency have been obtained; firstly in Ukraine, geometric and strong parameters of the femoral bone in patients with proximal hip fractures were analyzed, depending on the localization of the fracture, age and sex of patients; for the first time, a 10-year risk of osteoporotic fractures and hip fractures was determined using the Ukrainian version of FRAX in patients with proximal hip fractures before and after its appearance and proportion of people who needed antiostheoporotic treatment or densitometric examination before the appearance of the fracture were established; results – based on the analysis of short- and long-term mortality and survival of patients after proximal hip fractures, the main factors influencing them (age, sex of patients, the fact of hospitalization, surgical treatment) were highlighted; necessity of complex using of clinical risk factors of proximal hip fractures (age, gender, aggravated anamnesis of osteoporotic fractures and family history of proximal hip fractures), indicators of mineral density and geometry of the femoral bone, vitamin D level for to the risk assessment of fractures in the future and improvement the effectiveness of the treatment and rehabilitation measures has been proved; it was established the feasibility of only automatic densitometric measurement of the geometric indicators of the femoral bone using the method of structural analysis of the femoral bone with exploitation of two-photonic X-ray absorptiometry to assess the risk of proximal hip fractures. The expediency of using the Ukrainian version of FRAX in patients with risk factors of osteoporosis for prediction the risk of osteoporotic fractures and femoral fractures has been proved, this fact justifies its wider using in clinical practice in patients with low-traumatic fractures in anamnesis of life; implemented into the educational process at the department of age-related changes of musculosceletal system of Institute of Gerontology named D.F. Chebotarev NAMS Ukraine, Surgical Department of Danylo Halytsky Lviv National Medical University, into the clinical practice of Trauma department of Lviv City Clinical Emergency Hospital, Central Regional Clinical Hospital of Vinnytsya City, Consultative and Diagnostic department of Sytenko Institute of Spine and Joint Pathology National Academy of Medical Sciences of Ukraine, Orthopedic and Trauma Department of Research Institute for Rehabilitation of Persons with Disabilities of the Educational and Scientific Treatment Complex of National Pirogov Memoraial Medical University, Vinnytsya; the application area is the medical and diagnostic process of specialized traumatology departments, centers for emergency medical care and disaster medicine, scientific and pedagogical processes of the departments of traumatology and orthopedics, emergency medical care of medical institutions.

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