Otychenko O. Composite material based on biogenic hydroxyapatite with magnetic additives for biomedical using.

The dissertation is devoted to solving the actual scientific and technical problem of development of composite materils based on biogenic hydroxyapatite and magnetite (FeO∙Fe2O3) which will promote improvement of regenerative processes in case of implantation due to direct supply of trace elements (Ca, P, Fe), which will facilitate the visualization of local changes at the site of implantation due to increased X-ray contrast and will allow to local fight with bacteria. A chemical method for obtaining a powder composite material based on biogenic hydroxyapatite and magnetite (FeO∙Fe2O3) is proposed, which provides a more stable set of physicochemical properties compared while maintaining the main phase of hydroxyapatite. It is shown that the developed chemical method of obtaining composite materials promotes the formation of a more perfect crystal lattice with a degree of crystallinity of 77–86%, while the degree of crystallinity of powders obtained by the combined method is 71–81%. It was found that the use of the composite material biogenic hydroxyapatite / iron oxide (FeO∙Fe2O3) as a possible carrier of the drugs prevents the formation of undesirable products of interaction of the antibiotic ceftriaxone with calcium phosphate materials. It was found that the samples of composite materials obtained by the proposed chemical method, after heat treatment in nitrogen and vacuum for the first 3 days of observations affect the growth of transgenic CHO cell line similar to unmodified biogenic hydroxyapatite, indicating a sufficient level of biocompatibility in the studied samples for medical supplies. Key words: hydroxyapatite, biogenic hydroxyapatite, iron oxalate, magnetite, iron oxide, composite materiаl, doping, crystal structure, adsorption activity, antibiotic.