The dissertation is devoted to the development and deepening of theoretical and practical issues of the complex cluster organization of the economy, on the basis of which the ways of increasing the efficiency of regional management, contributing to the improvement of the quality of life in market conditions and meeting the needs of the population, are proposed. The study shows that as an adequate methodological basis for management processes in domestic territories, it is necessary to use systems theory as the most general and at the same time take into account the specifics of a complex cluster organization. Nowadays, it becomes obvious that technologies for the implementation of complex cluster programs and projects are complex self-generated branched systems with many inputs and outputs. In the course of the study of the vital activity and viability of the territories on the example of the regions of the Ukrainian Black Sea region and comparison of the main indicators with the countries of Western Europe, a steady tendency towards serious upholding in socio-economic development was revealed. This is especially negatively reflected in the studies of many authors concerning the effectiveness of reforms, it is concluded that the built system of institutions that regulate economic processes has led to the fact that the problem of efficiency and sustainability of the development of the territory and its management is of particular importance. Currently, clusters are relevant and effectively operating structures, which is confirmed by the developments of domestic and foreign scientists and practitioners. The theory of cluster organization of the economy should be supplemented and developed taking into account the current state of the economy. The study made an assumption about the objective nature of clustering processes, i.e. their subordination to the action of the general laws of the development of the nature of this phenomenon, which may require the use of a retrospective-evolutionary approach to the study of clustering processes against the background of specific stages in the development of society and science, including territorial administration. Analytical studies of the territorial economy have shown that com-clusters should be considered as a new structural element in the territorial-production organization. In this regard, the issues of restructuring intraregional interaction are considered and a structural model of the region based on the cluster organization is developed. The author has defined the content and introduced the following terms into scientific circulation: "universal structure of clusters", "comcluster", "regional complex cluster". A structural model of a comcluster has been developed, which combines many subclusters, the laws of bond formation and the principles of intra-cluster interaction; integration of sub-clusters; vertical cooperation and horizontal coordination; selective competition and cooperation; an unbreakable chain of added value accumulation; responsibility for the reliability and stability of intra-cluster relations; responsibility for the quality of socio-economic interactions; harmonization of socio-economic interests; awareness; mutually beneficial innovation; development motivation. The necessity of improving the efficiency of management and the quality of life of the population of the territory from the standpoint of synergizing inter-cluster interaction in accordance with the established and formalized rules for developing a control action, taking into account the peculiarities of the control system, the parameters of subclusters, the parameters of their interaction and the degree of influence of the external environment. A mathematical model of the cluster control law has been developed. A matrix of functions for managing the cluster is proposed; forecasting and modeling of future states; planning the parameters of intra-cluster interaction; rationing (development of socio-economic standards); organization of intra-cluster interaction; vertical and horizontal coordination; motivation for cooperation and development; monitoring (accounting, control, research, pre-planned research, ratings, preparation of mega-management impact); in accordance with the stages of the life cycle: formation, functioning, development.