Havalko A. The role of hypoxia in impaired glucose tolerance in the elderly and ways of correction

The dissertation presents data on changes in resistance to hypoxia and stress reactivity of the cardiorespiratory system in elderly people with impaired glucose tolerance. Also presented are the results of the course application of interval normobaric hypoxic training and quercetin on the detected disorders. It was established that the body's resistance to the effects of hypoxia decreases in elderly people with impaired glucose tolerance. It was shown that under conditions of dosed hypoxia in elderly people with impaired glucose tolerance, compared to people with preserved glucose tolerance, there is a greater decrease in glucose concentration against the background of a smaller decrease in insulin concentration, which indicates a decrease in insulin resistance. It has been proven that impaired glucose homeostasis in the elderly is associated with a decrease in the vasomotor function of the endothelium of microvessels and an increase in sympathetic activity. It was established that in elderly people with impaired glucose tolerance, in response to hypoxia, the ventilatory response is reduced and at the same time the stress response of the autonomic nervous and cardiovascular systems is increased. It has been proven that the low level of HIF-1α mRNA expression is one of the factors in reducing the body's resistance to hypoxia in elderly people with both preserved and impaired glucose tolerance. New approaches to the correction of reduced body resistance to hypoxia, impaired glucose homeostasis, stress response of the cardiorespiratory system to hypoxia, HIF-1α mRNA expression and leukocyte telomere length in elderly people with impaired glucose tolerance using interval normobaric hypoxic training or quercetin were substantiated and tested.