Kozyts'ka S. Interrelation of Energetic and Constructive Metabolism in staphylococcus strains resistant to antibiotics

The dissertation is devoted to the investigation of the energetic and constructive metabolism reactions in staphylococcus strains sensitive and resistant to some antibiotics.The investigation results have shown that staphylococcus strains resistant to antibiotics are characterized by the intersification of Carbohydrates glycolitic splitting reactions.It is shown that glucose is oxidized more actively by resistant variants, and acetate and pyruvate are oxidized by sensitive strainsю.Citrate syntase key enzyme activity in resistant strains is increased on the fumarase intensification background.In is determined that the activity of biosynthetic enzymes, alanin transaminase and aspartat transaminase and also acetyl-KoA-carboxylase activity is higher in resistant variants on the average on 20-89%.The involrement of protein and nucleic acids labelled predecessors into staphylococci cells more intensive in resistant variants compared to the initial sensitive strain.