Zavelevych M. Effects of interferons on the state of 2-5 olygoadenylate system in cancer cells and virus-infected cells and modulation of these effects by retinoids

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0499U001172

Thesis Registration Form

0499U001172.pdf

Applicant for

Specialization

  • 14.01.07 - Онкологія

19-05-1999

Specialized Academic Board

Д 26.155.01

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Essay

The susceptibility of the cells under study to interferons has been analysed in vitro by the 2'5' oligoadenylate synthetase assay. The modulation of interferon effects by retinoids in cancer cells has been shown to be partially mediated by 2'5'-oligoadenylate system. Analysis of synthetase reaction products in cell-free system suggested that natural tRNA could serve as the activators of. 2'5' oligoadenylate synthetase

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