Nikolayenko I. Production and comparative analysis of hybridomas secreting monoclonal antibodies able to differentiate between vaccine and virulent polioviruses of the I, II and IIІ type.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0499U001261

Applicant for

Specialization

  • 03.00.06 - Вірусологія

21-05-1999

Specialized Academic Board

Д 26.003.01

Essay

Obtaining and using a new set of monoclonal antibodies for the intratype differentiation of polioviruses in the respous of virus-neutralisation. The methods of investigation: virusological,immunological and methods of the hybridome technology. The theoretical and practical results: obtained was a new set of polioviruses between each of three types; studied were possibilities of; is practical compared to other methods for the differentiation of polioviruses. A degree of the implementation: recommendations for using the set of monoclonal antibodies developed in the differentiation of field poliviral isolates (certificate of implementation enclosed). A sphere of use: virusological laboratories of Sanitary/Epidemiological Stations and Research Institutes.

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