Kolybo D. Antigenic structure of protective proline-rich region 536-566 of pertactin (Р.69) - pertussis adhesive factor

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0499U001381

Thesis Registration Form

0499U001381.pdf

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

28-05-1999

Specialized Academic Board

Д 26.220.01

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

Essay

Pertactin (Р. 69) - B.pertussis adhesive factor. Epitope mapping of synthetic peptides overlapping the pertactin region 536-566. ELISA, chromatography, isoelectric focusing, immunoblotting. The antigenic structure of region 536-566 of pertactin was studied, location of 5 sequential epitopes from this region was determined. It was shown that immunoblotting of the serum antibodies provides a possibility for analysis of cross-reactions of peptide-specific antisera. The approach for revealing the antibodies to the conjugated peptides in the presence of the antibodies to the cross-linking agent was proposed. Bioorganic chemistry, medicine.

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