Rybak V. Joint action of crown-ether and quaternary onium salts in liquid-solid interphase transfer catalysis.

Hydrolysis and aminolysis reactions of activated esters in liquid/solid phase-transfer catalysis conditions/ Study on joint action of crown-ehters and quaternary onium salts as phase-transfer catalysts. Elemental analysis, UV spectrophotometry (SF-46, Specord M-40), titrimetry (pH-121) in non-aqueous medium. Synergistic effect of catalytic couple crown-ester - quaternary onium salt has been found established and estimated quantitatively. Systematic studies on effects of water and methanol, added the nature of organic solvent and substrate structure have been carried out. Regularities established make it possible to determine the conditions necessary for manifestation of synergistic effect in liquid/solid phase system. Experimental data obtained, conclusions and recommendations are usable in peptide synthesis.