Zinchenko V. Regularities and mechanisms of forming and overcoming the resistance of tumor cells..

The thesis is devoted to study of the mechanisms of orming the resisrance to the effect of ionising radiation in tumor cells. Formodellig the radioresistance (RR) process there are received RR strains - variations of Guerin carcinoma and Pliss lymphosarcoma in rats, cultures of transformated fibroblasts L929 . An evidences of changes in subpopulation content of Guerin carcinoma and appearance of adaptive signs (various forms of internuclear cooperation) are obtained. In the result of mathematical analysis and modelling of RR inducation the most typical morphological changes in tumor cells and yeilding to the quantitative estimation signs are defined. On the basis of these signs the alporithm for detection of the tumor RR rate suitable for clinico-diagnostic use has been developed. Biochemical adaptive processes in the repeated course radiation of tumos-inducation of stress proteins, increase of nonprotein tiol group concentrations in tumos are determined. Hyperhemy and chemical radiosensinogens such as complex of microelements and low doses of taxol are used for overcoming RR of tumor cells.