Karpov O. The molecular complexes of single-stranded polyribonucleotides with intercalators as a type I interferon inducers

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0500U000119

Thesis Registration Form

0500U000119.pdf

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

21-04-2000

Specialized Academic Board

Д 26.220.01

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

Essay

A new approach of interferon synthesis stimulation has been elaborated based on the concept of the directed complex interferonogen construction containing both single-stranded RNA and synthetic ligands. It was shown that some intercalators contained complexes are able to induce stable double-stranded RNA regions formation depending on a lot of conformational changes.Using a model molecular complex containing yeast RNA and tiloron the author evaluates interferonogenesis as well as antiviral and immunomodulating effect of inducers constructed and also their toxicity levels. A hypothesis concerning general interferon induction mechanism has been proposed.

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