Klymenko T. Sexual and biorhythmological aspects of clinical course, diagnosis and treatment of newborns with asphyxia

Thesis contains results of clinical laboratory, instrumental and pathomorphological research of degree and character of central nervous system affection in 192 newborns of different sex undergone asphyxia. It is revealed and presented a sexual dimorphism in reactivity and adaptivity of neuroendocrine system based on the figures of stress hormones and biologically active substances in healthy newborns born through natural maternal passages. A significant role of brain epiphysis in adaptation is defined and sexual peculiarities of pineal gland biorhythmological functions in healthy newborns is determined. There were shown clinical neurophysiological parallels in sexual dimorphism in grave and medium grave CNS affection as mainly right-side brain affection and more manifested and prolonged intracranial hypertension syndrome in boys, it was proved their prognostic value. Pathomorphological criteria of sexual peculiarities of neuroendocrine system of dead on birth and died newborns were studied and identif ied considering stability, organization and compensation of CNS structural functional changes. Value of sexual peculiarities of neurohormonal reactivity and adaptivity in realization of various affections and clinical course in hypoxic affected CNS was emphasized. Higher reactivity and optimal dynamics of neurohormonal response in girls than in boys in asphyxia are connected with increased resistance to cerebral affections. To elaborate new methods of diagnosis, therapy and prevention it is necessary to search general biological laws in sexual dysmorphia in neonatology. The result of the investigation was introduced into practice of obstetrical establishments of Kharkiv, Rovno, Kiev, in medical education department of Kharkiv and Odessa.