Chorna V. Cysteine cathepsins in conditions of irradiation injury and malignant growth

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0501U000327

Thesis Registration Form

0501U000327.pdf

Applicant for

Specialization

  • 03.00.01 - Радіобіологія

22-10-2001

Specialized Academic Board

Д 26.001.24

Taras Shevchenko National University of Kyiv

Essay

It was established, that the changes of activity, localisation and physicochemical properties of lysosomal cysteine cathepsins B,L,Н in various brain regions and in blood serum testify to characteristic differences in a system of proteolysis under effect of the total 50, 100, 200 Gy and under total single and fractional irradiation by 0,25 Gy dose. Irradiation and effect of x-ray irradiation and the hypoxia lead to opposite changes of cathepsins activity in a tumor and tissues of that rats. These alteration is depend on changes of a radiation dose and condition, of tumor growth stage and effect of x-ray destruction of tumors.

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