To improve the diagnosis and treatment of vegetative dysfunction in children, certain features of blood flow, vegetative homeostasis, hemodynamics and neuroendocrine disorders in various clinical forms of the disease were investigated. Using the complex clinical and laboratory examinations, four forms of vegetative dysfunction in children were revealed, i.e. neurocirculatory (NCD), vegetative-vascular (VVrD), vegetative-visceral (VV1D) and paroxysmal vegetative insufficiency (PVI), which were characterized by various levels of damaging VNS and conditions of vegetative homeostasis, and required an individualized approach to the treatment. For the first time, it was shown, that in NCD simultaneous increases in tonus of sympathetic and parasympathetic departments of VNS were observed, whereas in children suffering from VSD, significant rises in activity were observed in both the sympathetic department of VNS and the central contour of regulation. In children suffering from PVI, significant decreases were revealed in activity both the sympathetic and parasympathetic departments of VNS as well as concurrent strengthening the autonomic sinus junction, and shifting the adaptation-compensatory mechanisms of the central regulation contour of cardiac activity. In children suffering from vegetative dysfunction, there were observed disorders in central, peripheral and cerebral hemodynamics, which were characterized by various clinico- pathogenetic forms of vegetative disorders. For the first time, essential changes were established in the microcirculatory bed, central, peripheral and cerebral hemodynamics. which were typical for various forms of vegetative dysfunction, such as neurocirculatory, vegetative-vascular, vegetative-visceral and paroxysmal. For the first time, a classification was offered as well as diagnostic criteria for clinico-pathogenetic forms of vegetative dysfunction in children that required an individualized approach to the treatment. The necessity for the treatment was proved, and the estimation o f treatment efficacy in children with vegetative dysfunction was carried out. It was shown that supplementation of the complex therapy with Instenon and Tanacan normalized vegetative homeostasis and microcirculation and improved parameters of the central, cerebral and peripheral hemodynamics.
