Gorbenko N. Pathogenic basis of succinic acid derivative - phensuccinal efficacy in therapy of diabetes mellitus and its complications (experimental study)

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0505U000014

Thesis Registration Form

0505U000014.pdf

Applicant for

Specialization

  • 14.01.14 - Ендокринологія

16-12-2004

Specialized Academic Board

Д 64.564.01

State Institution “V.Ya.Danilevsky Institute of Endocrine Pathology Problems of Academy of Medical Sciences of Ukraine”

Essay

It was proved that phensuccinal stimulated regeneration and secretion function of pancreatic beta-cells and protected ones from the destruction by diabetogenic agents. Administration of phensuccinal decreased geterogenous insulin resistance, attenuated diabetic micro- and macroangiopathy development in absolute and relative insulin insufficiency. Possible molecular mechanisms of multifactorial antidibetic action of phensuccinal (improvement of bioenergetics processes and suppression of oxidative stress in mitochondria and decrease of non-enzymatic glycosilation in diabetic animals were established. The results of investigation are used as theoretical substantiation of clinical trials of phensuccinal as potential antidiabetic agent.

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Files

АвторефератГорбенко.doc

Диссертация Горбенко.doc

Диссертация Горбенко.doc

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